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Spadin is a nootropic peptide.
| Name | Spadin |
|---|---|
| CAS No. | 1270083-24-3 |
| Synonyms | H-TYR-ALA-PRO-LEU-PRO-ARG-TRP-SER-GLY-PRO-ILE-GLY-VAL-SER-TRP-GLY-LEU-ARG-OH |
| Specifications | 98% |
| Appearance | White crystalline powder |
| Molecular Formula | C96H142N26O22 |
| Molecular Weight | 2012.32 |
| Storage | Store in refrigerator at 4°C, tightly sealed, away from heat, light and moisture. |
Spadin is a potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.
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